We previously developed at the UNICOG unit a large collection of hundred of individual functional circuits using a short 5 minutes localizer (Pinel et al., 2007). This database was proved to be efficient to isolate correlated functional hemispheric asymmetries between language and arithmetic (Pinel et al., 2009) or correlation between variation in language brain activation and genetic polymorphism (Pinel et al. 2012, Le Floch et al., 2012). To extend this logic, we aimed to develop four functional localizers who cover a larger range of human cognitive skills and that allow acquisition of individual fMRI maps in short time (protocols are described in detail in Pinel et al. 2018, submitted). :
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Localizer Pinel 2007 (originally develop in Pinel et al. 2007) - 5'05 minutes
Speech perception
Reading
Mental calculation
Motor action (button pressing)
Visual perception (checkerboard flickering)
Localizer Social I - 8'34 minutes
Animated triangle with interaction (inspired from Heider & Simmel 1944)
Theory of mind task (False belief, inspird from Baron-Cohen et al. 1985)
Human vocalization perception (from Belin et al. 2000)
Localizer Social II - 7'15 minutes
Trustworthiness estimation (from Lundqvist et al. 1998 / Winston et al. 2002)
Eyes intention perception (from Baron-Cohen et al. 1997)
Localizer Parietal - 8'08 minutes
Object grasping
Ocular saccades
Hand mental rotation
This set of localizers was applied to 79 subjects to create a first collection of individual functional circuits included in the CONNECT/Archi database (Assaf et al., 2013). The design of the functional protocols was created by Philippe Pinel, with the help of Baudoin Forgeot d’Arc, under the supervision of Stanislas Dehaene and Thomas Bourgeron. The acquisition of the CONNECT/Archi database was designed under the supervision of Cyril Poupon and Jean-François Mangin, and was funded by the Federative Research Institute 49, the HIPPIP European grant, and the European CONNECT project (http://www.brain-connect.eu).
References
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Belin P, Zatorre RJ, Lafaille P, Ahad P, Pike B. 2000. Voice-selective areas in human auditory cortex. Nature 403:309-312.
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Heider F. & Simmel M. 1944. An experimental study of apparent behavior, American Journal of Psychology, vo. 57, p. 243-259.
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Le Floch E, Guillemot V, Frouin V, Pinel P, Lalanne C, Trinchera L, Tenenhaus A, Moreno A, Zilbovicius M, Bourgeron T, Dehaene S, Thirion B, Poline JB, Duchesnay E. 2012. Significant correlation between a set of genetic polymorphisms and a functional brain network revealed by feature selection and sparse Partial Least Squares. Neuroimage, 63(1), 11-24.
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Lundqvist, D., Flykt, A., & O ̈ hman, A.1998. The Karolinska Directed Emotional Faces - KDEF, CD ROM from Department of Clinical Neuroscience, Psychology section, Karolinska Institutet, ISBN 91-630-7164-9.
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Pinel P, Thirion B, Meriaux S, Jobert A, Serres J, Le Bihan D, Poline JB and Dehaene S. 2007. Fast reproducible identification and large-scale databasing of individual functional cognitive networks. BMC Neuroscience, 8, 91.
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Pinel P and Dehaene S. 2009. Beyond Hemispheric Dominance: Brain Regions Underlying the Joint Lateralization of Language and Arithmetic to the Left Hemisphere. Journal of Cognitive Neuroscience, 22(1), 48-66.
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Pinel P, Fauchereau F, Moreno A, Barbot A, Lathrop M, Zelenika D, Le Bihan D, Poline JB, Bourgeron T, Dehaene S (2012). Genetic variants affecting FOXP2 and KIAA0319 are associated with altered brain activation. Journal of neuroscience, 18, 817-825.
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Winston J, Strange B, O'Doherty J, Dolan R. 2002. Automatic and intentional brain responses during evaluation of trustworthiness of faces. Nature Neuroscience:277-283.
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